Polycystic Ovaries

Dr. Panagiotis Polyzos MD PhD MSc

Obstetrician Gynaecologist
Doctor of Medicine, University of Athens Medical School

Panagiotis Polyzos, Gynaecologist Obstetrician, is active at the Institute of Life - IVF Unit of Iaso Maternity Hospital.

Contents

Πολυκυστικές ωοθήκες – σύνδρομο PCOS

Polycystic Ovaries

What are polycystic ovaries?

In Polycystic Ovary Syndrome (PCOS), the hormonal balance is disrupted, and ovulation does not occur regularly (or occurs rarely). The ovaries become enlarged and filled with many small cysts. It is a common endocrine disorder affecting women of reproductive age, occurring in about 5–10% of this population.

It is also considered one of the leading causes of infertility. PCOS is a hormonal disorder commonly seen in women of reproductive age. Women with PCOS may have infrequent or prolonged menstrual periods or excessive levels of male hormones (androgens). The ovaries may develop many small fluid-filled follicles that fail to regularly release eggs.

The exact cause of PCOS remains unknown. Early diagnosis and treatment, combined with weight loss, can reduce the risk of long-term complications such as type 2 diabetes and heart disease.

Polycystic ovary syndrome is typically associated with menstrual disorders, infertility, obesity and shaggy hair.

PCOS is typically associated with menstrual irregularities, infertility, obesity, and hirsutism. It is the most common gynecological endocrine disorder and affects 5–10% of women aged 12–45.

Women with PCOS often have a mother or sister with similar symptoms. Diagnostic evaluation may include blood hormone testing, glucose and insulin measurements, abdominal and/or transvaginal ultrasound, MRI, laparoscopy, and ovarian biopsy.

What are the symptoms of Polycystic Ovaries?

PCOS signs and symptoms often appear around the time of the first menstrual period (menarche), but sometimes develop later—for example, after significant weight gain. Symptoms vary greatly.

PCOS is diagnosed when at least two of the following criteria are present:

  1. Irregular periods. Infrequent, irregular, or prolonged menstrual cycles are the most common sign of PCOS. For example, you may have fewer than nine periods a year, more than 35 days between periods, and unusually heavy periods.
  2. Excess androgens. Increased levels of male hormones can lead to physical signs such as excessive hair growth on the face and body (hyperpigmentation) and occasionally severe male pattern acne and baldness.
  3. Polycystic ovaries. Your ovaries may be enlarged and have multiple follicles surrounding the eggs. As a result, the ovaries may not function normally.

The signs and symptoms of PCOS are usually more severe if you are obese. The syndrome and symptoms often begin to appear with menopause. In some cases, the syndrome develops later during reproductive age with various signs and symptoms, which can worsen in conjunction with significant weight gain. Each woman with polycystic ovary syndrome may be affected differently.

When should you see a doctor?

Seek medical advice if you have concerns about menstrual irregularities, infertility, or symptoms of androgen excess, such as hirsutism, acne, or hair loss.

What factors and causes are responsible?

The exact cause is unknown, but contributing factors may include:

  1. Excessive insulin production. Insulin is the hormone produced in the pancreas that allows cells to use sugar, your body's main source of energy. If your cells become resistant to the action of insulin, then your blood sugar levels can rise, and your body can produce more insulin. Excess insulin can increase androgen production, causing difficulty in ovulation. Research has shown that women with PCOS have a type of low-grade inflammation that stimulates the polycystic ovaries to produce androgens, which can lead to heart and blood vessel problems.
  2. Heredity. Research shows that certain genes may be linked to PCOS.
  3. Excess androgens. The ovaries produce abnormally high levels of androgens, resulting in hyperpigmentation and acne.

What problems can polycystic ovaries cause? What are the complications?

Complications of PCOS can include:

  • Infertility
  • Gestational diabetes or pregnancy-induced hypertension
  • Miscarriage or preterm birth
  • Non-alcoholic steatohepatitis - a severe liver inflammation caused by a build-up of fat in the liver
  • Metabolic syndrome - a cluster of conditions including high blood pressure, high blood sugar and abnormal cholesterol or triglyceride levels that significantly increase the risk of cardiovascular disease
  • Type 2 diabetes or prediabetes
  • Sleep apnea
  • Depression, anxiety and eating disorders
  • Abnormal uterine bleeding
  • Endometrial cancer

Obesity is often associated with PCOS and can worsen complications.

How are polycystic ovaries diagnosed?

There is no single test for definitive diagnosis. Your doctor will begin with a medical history review focusing on menstrual cycles and weight changes. A physical exam may assess hair growth, insulin resistance, and acne.

Find a solution to your problem.
Schedule your appointment

Your doctor may then recommend:

Blood tests

Your blood may be analyzed to measure hormone levels. This test can help rule out other causes of menstrual irregularities or excess androgens that mimic PCOS. Additional blood testing may be performed to assess glucose tolerance and fasting cholesterol and triglyceride levels.

Ultrasound

Your doctor will examine the appearance of your ovaries and the thickness of your endometrium using a transvaginal ultrasound.

If PCOS is diagnosed, your doctor may recommend further testing for possible complications. These may include:

  • Periodic monitoring of blood pressure, glucose tolerance, and cholesterol and triglyceride levels
  • Screening for depression and anxiety
  • Screening for obstructive sleep apnea

Is there a cure? And if so, what is it?

Treatment is tailored to each woman’s symptoms, such as excess hair growth, acne, obesity, and infertility. Weight management through diet and moderate exercise is essential. Even a 5% weight reduction can significantly improve the condition.

Medical guidance from a gynecologist is critical.

What is the role of diet in polycystic ovaries?

Women with PCOS should pay particular attention to diet — often with the help of a specialist dietitian. Regular exercise combats insulin resistance, lowers blood sugar levels, and helps maintain a healthy weight. Early diagnosis and treatment, including weight loss, reduce long-term risks such as diabetes and cardiovascular disease, and can improve fertility significantly, unless other fertility factors coexist.

Lifestyle changes

Your doctor may recommend weight loss if you are overweight, through a low-calorie diet combined with moderate exercise. Even a modest reduction in weight — for example, losing 5% of your body weight — can improve your condition.

Weight loss may also increase the effectiveness of medications prescribed for PCOS and can help improve fertility.

Medicines

To regulate your menstrual cycle, your doctor may recommend:

  • Combined hormonal contraceptive pills. Pills that contain estrogen and progestin reduce androgen production and regulate estrogen levels. Balancing your hormones may reduce the risk of endometrial cancer and help correct abnormal bleeding, excessive hair growth, and acne. Instead of pills, you may use a skin patch or vaginal ring that contains a combination of estrogen and progestin.
  • Progestin therapy. Taking progestin for 10 to 14 days every one to two months can regulate your periods and protect against endometrial cancer. Progestin therapy does not improve androgen levels and will not prevent pregnancy. The progestin-only pill or a progestin-releasing intrauterine device (IUD) may be a better option if you also wish to avoid pregnancy.

 

To help you ovulate, your doctor may recommend:

  • Clomiphene. This oral anti-estrogen medication is taken during the first part of your menstrual cycle.
  • Letrozole (Femara). Originally used as a breast cancer treatment, this medication can stimulate the ovaries to induce ovulation.
  • Metformin. This oral medication for type 2 diabetes improves insulin resistance and lowers insulin levels. If you do not become pregnant using clomiphene alone, your doctor may recommend adding metformin. If you have prediabetes, metformin may also slow the progression to type 2 diabetes and support weight loss.
  • Gonadotropins. These hormonal medications are administered by injection.

 

To reduce excessive hair growth, your doctor may recommend:

  • Oral contraceptive pills. These pills reduce androgen production, which can help decrease excessive hair growth.
  • Spironolactone (Aldactone). This medication blocks the effects of androgens on the skin. Spironolactone can cause birth defects, therefore effective contraception is required while taking it. It is not recommended if you are pregnant or planning to become pregnant.
  • Eflornithine (Vaniqa). This topical cream can slow down facial hair growth in women.
  • Electrolysis. A tiny needle is inserted into each hair follicle, delivering an electrical pulse to damage and ultimately destroy the follicle. Multiple treatment sessions may be necessary.

 

To reduce the effects of PCOS, try to:

Maintain a healthy weight. Weight loss can lower insulin and androgen levels and may help restore ovulating. Ask your doctor about a weight-management program and meet regularly with a dietitian to support your weight-loss goals.

Limit carbohydrates. Low-fat, high-carbohydrate diets may increase insulin levels. Ask your doctor about a low-carbohydrate diet if you have PCOS. Choose complex carbohydrates, which raise blood sugar levels more slowly.

Stay active. Exercise helps lower blood sugar levels. If you have PCOS, increasing your daily physical activity and participating in a regular exercise program can treat or even prevent insulin resistance and help you maintain a healthy weight and prevent diabetes.

Polycystic Ovaries and Pregnancy

Polycystic Ovary Syndrome can increase certain risks during pregnancy. Some of these may include miscarriage, preterm birth, gestational diabetes, and generally more challenging labor and delivery. However, this is not always the case. It is important to consult your gynecologist, who will thoroughly assess your situation and recommend the best possible approach for your pregnancy.

How do polycystic ovaries affect mental health?

Women with polycystic ovaries have a higher likelihood of experiencing mental health disorders, according to research. Studies show that PCOS can negatively impact mental well-being, affecting an estimated 5% to 10% of the global population. Similarly, children born to mothers with PCOS may be at increased risk of attention-deficit or hyperactivity-related disorders.

Can I get pregnant with polycystic ovaries?

Having an ultrasound and receiving a diagnosis of polycystic ovaries does not necessarily mean that you will experience fertility problems. However, Polycystic Ovary Syndrome can affect fertility and may also impact egg quality.

It is important to consult with your doctor, who will explain your individual situation in detail. The good news is that many women with PCOS are able to become pregnant without needing specialized treatment. Age is certainly an important factor that will influence fertility, depending on your medical history and the severity of the condition.

What tests are needed? Do I need an ultrasound?

For an accurate diagnosis, the appropriate tests must be carried out to confirm that a woman has Polycystic Ovary Syndrome. This includes a series of hormonal blood tests, as well as an ultrasound scan where we expect to identify abnormal follicles and any other issues affecting the ovaries or the uterus.

MEDIA

Watch us on Youtube

Προγεννητικός έλεγχος κατά την εγκυμοσύνη

Interview in the TRT show “Central Greece Good Evening”

TESTIMONIALS

They said about us