Uterine Polyps: Symptoms, Causes and Removal

Dr. Panagiotis Polyzos, obstetrician gynecologist in Athens
Dr. Panagiotis Polyzos MD PhD MSc

Obstetrician-Gynecologist
PhD, University of Athens Medical School

Obstetrician-gynecologist Panagiotis Polyzos practices at the Institute of Life, the IVF Unit of IASO Maternity Hospital.

Contents

Uterine polyps: anatomical illustration

Uterine polyps: what you need to know

What are uterine polyps?

Uterine polyps are abnormal, excessive growths (hyperplasia) of the glands and stroma of the uterus that extend from its inner lining and project into the uterine cavity. The overgrowth of cells in the endometrium leads to the formation of uterine polyps, also known as endometrial polyps. These polyps are usually benign, although some may be cancerous or can eventually turn into cancer (precancerous polyps). Uterine polyps range in size from a few millimeters (about the size of a lentil) to several centimeters (the size of a golf ball or even larger). They are attached to the uterus by a broad base or a thin stalk.

A woman may have one or more uterine polyps. They are usually found in the body of the uterus, but occasionally they appear in the cervix as well as in the vagina. Uterine polyps occur more often in women who are going through or have completed menopause, although younger women may also develop them.

Uterine polyps: what are the symptoms?

Symptoms of uterine polyps may include:

  • Abnormal menstrual bleeding, for example frequent, unpredictable periods of variable length and heaviness
  • Intermenstrual bleeding
  • Menorrhagia
  • Infertility

What are the causes?

Hormonal factors appear to play a major role. Uterine polyps are estrogen-dependent, meaning they grow in response to circulating estrogen.

Risk factors

Risk factors for developing uterine polyps include:

Are there any complications?

Uterine polyps may be directly linked to infertility. If you have uterine polyps and are unable to have children, removing the polyps may allow you to get pregnant, but the evidence is unclear.

How is it diagnosed?

If your doctor suspects uterine polyps, one or more of the following diagnostic tests may be performed:

  • Transvaginal ultrasound: The doctor may detect a clearly visible polyp or identify thickened endometrial tissue suggesting a polyp.
  • Saline infusion sonography (SIS): Sterile saline is infused into the uterine cavity during ultrasound to improve visualization.
  • Hysteroscopy. Your doctor inserts a thin, flexible, lighted telescope (hysteroscope) through your vagina and cervix. Hysteroscopy allows your doctor to examine the inside of your uterus.
  • Endometrial biopsy: A sample of endometrial tissue is collected for laboratory analysis. Polyps can be confirmed through histological examination.

Most uterine polyps are benign. However, some precancerous endometrial changes (endometrial hyperplasia) or endometrial cancer may initially appear as polyps. Your doctor will likely recommend polyp removal so the tissue can be examined to rule out cancer.

What is the proper treatment? Can polyps be removed?

Depending on your condition, your doctor may recommend:

  • Watchful waiting: Small asymptomatic polyps may resolve on their own. Treatment may not be necessary unless there is a cancer risk.
  • Medication. Certain hormonal medications, such as progesterone  and gonadotropin-releasing hormone agonists, may reduce polyp symptoms. However, taking such medications is usually a short-term solution, since symptoms usually return once you stop taking them.
  • Surgical removal. During hysteroscopy, the polyps can be excised (removed). If a uterine polyp contains cancer cells, your doctor will talk with you about the next steps in evaluation and treatment.
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Do polyps recur?

In some cases, polyps may come back. Options include a hormonal IUD, which causes endometrial atrophy, or cauterization of the endometrium with diathermy (in women who no longer wish to have children).

In women being treated with tamoxifen, the picture is much more complex and management must be individualized.

Endometrial polyps and cervical polyps: how they differ

The same term is often used, but these are two different lesions.

  • Endometrial polyp: grows inside the uterine cavity. It cannot be seen on a simple exam and is detected by ultrasound or hysteroscopy. This is the type linked to menstrual disorders, infertility and, rarely, cancer.
  • Cervical polyp: grows in the cervical canal and is often visible during a speculum exam as a small red bump at the opening of the cervix. It usually causes spotting after intercourse. It is almost always benign and is easily removed in the office.

A woman can have both at the same time. That’s why, when a cervical polyp is found in a woman with bleeding, the endometrium is checked too.

Which uterine polyps should be removed

Not every polyp needs to be removed. The decision is based on the risk of cancer, the symptoms and your plans for pregnancy. In large studies, the chance of cancer in a polyp in a premenopausal woman without symptoms is very low, below 1%. It increases after menopause, especially when there is bleeding.

Removal is recommended when:

  • the woman is past menopause and is bleeding,
  • there are symptoms, such as heavy or irregular periods,
  • the woman is trying to get pregnant or is preparing for fertility treatment,
  • the polyp is large, over about 1.5 centimeters, or there are many,
  • there are risk factors for endometrial cancer, such as taking tamoxifen, obesity or Lynch syndrome.

Monitoring may be an option for a younger woman with a small polyp found by chance, with no symptoms and no plans for pregnancy in the near future. Some small polyps go away on their own within a year. The follow-up is done by ultrasound early in the cycle, right after the period, when the endometrium is thin and the polyp is easier to see.

Hysteroscopic polyp removal: what to expect

Preparation

The procedure is usually scheduled in the first days after your period ends. In women of reproductive age, pregnancy is ruled out first. If it is done under anesthesia, you need to fast from the night before and have preoperative tests.

The procedure

Small polyps can be removed by office hysteroscopy, with a thin hysteroscope and without general anesthesia. Larger or multiple polyps are removed by operative hysteroscopy under sedation, with special instruments that cut the base of the polyp. The procedure usually takes 10 to 30 minutes, with no abdominal incisions.

After the procedure

  • Light bleeding or a watery discharge for a few days is expected.
  • Mild, period-like pain that is relieved by simple pain relievers.
  • Return to work usually the next day.
  • Avoid intercourse, tampons and baths in a bathtub or the sea for about one week, or as long as your doctor recommends.

The histology result usually comes back in one to two weeks. Contact us right away if you have a fever, bleeding heavier than a period, or pain that is getting worse. You will find more about the technique on the page about hysteroscopy.

Uterine polyps and fertility treatment

Inside the cavity, a polyp acts like a foreign body. It can cause local inflammation and change the environment where the embryo implants. Especially when it is close to the openings of the fallopian tubes, it can also make it harder for sperm to pass through.

  • Before IUI or IVF: the uterine cavity is checked by ultrasound, saline infusion sonography or hysteroscopy, and any polyp is removed before treatment starts.
  • If a polyp is found during stimulation: depending on its size, it may be decided to freeze the embryos and perform the embryo transfer in a later cycle, once the polyp has been removed.
  • After polypectomy: attempts to conceive or fertility treatment can usually resume from the next cycle, as long as the histology is benign.

A polyp or something else? The differential diagnosis

On a standard ultrasound, several conditions can look like a polyp. Telling them apart correctly changes the treatment:

  • Submucosal fibroid: a solid nodule of muscle tissue that projects into the cavity. It is firmer and has more blood vessels, and it often requires a different removal technique. See the page on uterine fibroids.
  • Endometrial hyperplasia: diffuse thickening rather than a localized mass.
  • Retained products of conception: after a miscarriage, abortion or delivery.
  • Adhesions or a uterine septum, which are better seen with hysteroscopy.
  • Endometrial cancer with a polypoid shape, mainly after menopause.

Saline infusion sonography, and above all hysteroscopy with biopsy, provide the certainty that a standard ultrasound cannot.

Uterine polyps after menopause

After menopause, a polyp is managed more strictly. Any bleeding, even a single spot, needs investigation. If the ultrasound shows a polyp in a woman who is bleeding, removal and histological examination are the rule. The reason is simple: at this age, the chance that a precancerous change or cancer is hiding there is higher. More about the signs and diagnosis on the page about uterine cancer.

Women taking tamoxifen after breast cancer have polyps more often, and they are often larger. Do not stop the medication. But report any vaginal bleeding or change in discharge to your gynecologist right away.

When to book an appointment for a checkup

  • Spotting between periods or after intercourse that keeps happening.
  • Periods that have suddenly become heavier or longer with no obvious cause.
  • Any bleeding after menopause.
  • Difficulty conceiving for 12 months, or 6 months if you are over 35.
  • Findings of a “thick endometrium” or a “possible polyp” on a routine ultrasound.

Bring your previous ultrasounds with you. Comparing them helps show whether the polyp is growing or shrinking.

Can uterine polyps be prevented?

No method guarantees that a polyp will not appear. However, because polyps feed on estrogen, certain choices lower the likelihood:

  • A healthy weight: fat tissue produces estrogen, especially after menopause.
  • The right hormone therapy regimen: in a woman who has a uterus, estrogen is always combined with a progestogen.
  • Hormonal IUD: in selected women whose polyps keep coming back, it keeps the endometrium thin.
  • Regulating cycles in women with infrequent periods, such as those with polycystic ovaries, so that the endometrium is shed regularly.

After removal, one ultrasound the following year, or sooner if symptoms return, is enough for most women.

Common misconceptions about polyps

  • “A polyp means cancer.” The vast majority of polyps are benign. Removal and histological examination are done to be certain, not because cancer is expected.
  • “Removal requires major surgery.” It is done through the natural opening, without incisions, and most women return to work the next day.
  • “A blind D&C is enough.” A simple scraping (curettage) without visual control can leave the polyp in place. Hysteroscopic removal under direct vision is current practice.
  • “Once it is removed, it won't come back.” A new polyp can appear, mainly when the hormonal factors are still there. Follow-up matters.

Polyps and contraception

Many women ask whether the birth control pill is to blame for a polyp. Combined contraceptives contain a progestogen, which keeps the endometrium thin, and they are not considered a cause of polyps. The hormonal IUD actually has a protective effect. However, if you have breakthrough bleeding that continues beyond the first months of using a method, do not automatically blame the product: an ultrasound will show whether there is a polyp or another cause.

Frequently Asked Questions

Is a uterine polyp dangerous?

Most polyps are benign. A small percentage may contain precancerous or cancerous cells, more often after menopause or when there is bleeding. That’s why a polyp that is removed is always sent for biopsy.

With hysteroscopy. A thin camera passes through the vagina into the uterus and the polyp is removed under direct vision, without incisions. You go home the same day.

It can make embryo implantation harder. Removing it improves the chances of conception, which is why it is recommended before IVF or IUI.

Yes, in some women polyps reappear after months or years. Regular ultrasound monitoring is needed.

Irregular or very heavy periods, spotting between periods or after intercourse, bleeding after menopause and difficulty conceiving. Many polyps cause no symptoms at all and are found by chance on ultrasound.

Not always. Small polyps are often removed by office hysteroscopy, with local pain relief or no anesthesia at all. For larger or multiple polyps, or when the woman prefers it, the procedure is done under sedation and you go home the same day.

Usually from the next cycle, once the histology is benign and the bleeding has stopped. For fertility treatment, your doctor will set the right timing.

Yes. Some small polyps, mainly those under one centimeter, go away on their own within a few months. That’s why, in young women without symptoms, a follow-up check may be done before deciding on removal.

There is no strong evidence that a small polyp causes miscarriage. In women with recurrent miscarriage, however, the uterine cavity is checked and any polyps or other abnormalities are treated.

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