Chlamydia: Symptoms, Diagnosis and Treatment

Dr. Panagiotis Polyzos, obstetrician gynecologist in Athens
Dr. Panagiotis Polyzos MD PhD MSc

Obstetrician-Gynecologist
PhD, University of Athens Medical School

Obstetrician-gynecologist Panagiotis Polyzos practices at the Institute of Life, the IVF Unit of IASO Maternity Hospital.

Contents

Chlamydia: a sexually transmitted infection

Chlamydia

What is chlamydia?

Chlamydia is a common sexually transmitted infection caused by the microorganism Chlamydia trachomatis. In men, it typically infects the urethra and epididymis, while in women it affects the cervix and fallopian tubes. In newborns of infected mothers, it can infect the eyes and lungs. The high prevalence of this infection is due to the fact that it often presents without any noticeable symptoms. When sexual partners are not treated simultaneously, they can repeatedly reinfect each other.

You may not realize you have chlamydia, as many individuals do not show signs or symptoms such as genital pain or abnormal vaginal or penile discharge.

Chlamydia trachomatis most commonly affects young women, but the infection can occur in both men and women of all ages. It is not difficult to treat, but if left untreated, it can lead to more serious health problems.

What are the main symptoms?

Early-stage Chlamydia trachomatis infections often cause few or no signs and symptoms. Even when symptoms do appear, they are usually mild, making them easy to overlook.

Symptoms and signs of a Chlamydia trachomatis infection may include:

  • Painful urination
  • Vaginal discharge in women
  • Penile discharge in men
  • Painful sexual intercourse in women
  • Bleeding between periods or after sexual intercourse in women
  • Testicular pain in men

Chlamydia can also infect the rectum, either without noticeable symptoms or with rectal pain, discharge, or bleeding. Chlamydial eye infections (conjunctivitis) may also occur through contact with infected bodily fluids.

When should you see a doctor?

Visit your doctor if you experience discharge from the vagina, penis, or rectum, or if you have pain during urination. You should also see your doctor if you learn that your sexual partner has chlamydia. Your doctor will likely prescribe an antibiotic even if you do not have any symptoms.

What are the main causes?

The bacterium Chlamydia trachomatis is most commonly transmitted through vaginal, oral, or anal sex. It is also possible for pregnant women to pass chlamydia to their babies during childbirth, causing pneumonia or a serious eye infection in newborns.

What are the risk factors?

Factors that increase the risk of developing a Chlamydia trachomatis infection include:

  • Being sexually active before the age of 25
  • Having multiple sexual partners
  • Inconsistent use of condoms
  • History of a sexually transmitted infection

What are the possible complications?

Chlamydia trachomatis may be associated with:

  1. Pelvic inflammatory disease (PID). PID is an infection of the uterus and fallopian tubes that causes pelvic pain and fever. Severe infections may require hospitalization for intravenous antibiotics. PID can damage the fallopian tubes, ovaries and uterus, including the cervix.
  2. 2. Infection near the testicles (epididymitis). A chlamydia infection can cause inflammation of the coiled tube located beside each testicle (epididymis). The infection can lead to fever, pain in the scrotum, and swelling.
  3. Prostate gland infection. Sometimes the chlamydia organism can spread to the prostate gland in men. Prostatitis may cause pain during or after sexual intercourse, fever and chills, painful urination, and lower back pain.
  4. Infections in newborns. Chlamydia infection can be passed from the vaginal canal to the baby during childbirth, causing pneumonia or severe eye infections.
  5. Ectopic pregnancy. This occurs when a fertilized egg implants and grows outside the uterus, usually in a fallopian tube. The pregnancy must be removed to prevent life-threatening complications such as tubal rupture. Chlamydia infection increases this risk.
  6. Infertility. Chlamydia infections, even those that cause no signs or symptoms, can cause scarring and blockage of the fallopian tubes, which can make women infertile.
  7. Reactive arthritis. People with Chlamydia trachomatis are at higher risk of developing reactive arthritis, also known as Reiter’s syndrome. This condition usually affects the joints, eyes, and urethra — the tube that carries urine from the bladder out of the body.

What is the appropriate prevention?

  1. Use condoms.
  2. Use a latex male condom or a polyurethane female condom during every sexual encounter. Condoms used correctly every time reduce, but do not eliminate, the risk of infection.
  3. Limit the number of your sexual partners.
  4. Having multiple sexual partners puts you at higher risk of contracting chlamydia and other sexually transmitted infections.
  5. Get regular screenings. If you are sexually active — especially if you have multiple partners — talk to your healthcare provider about how often you should be tested for chlamydia and other sexually transmitted infections.

How is the proper diagnosis made?

Sexually active women aged 25 or younger. The rate of chlamydia infection is highest in this group, so an annual screening test is recommended. Even if you have been tested in the past year, get tested when you have a new sexual partner.

Pregnant women. You should be tested for chlamydia during your prenatal checkups. If you are at high risk of infection, because of a new sexual partner or because your regular partner may have been infected, get tested again later in your pregnancy.

Women and men at high risk. Individuals with multiple sexual partners, those who do not consistently use condoms, or men who have sex with men should consider frequent screening for chlamydia. Other high-risk indicators include an active sexually transmitted infection and possible exposure through an infected partner.

Screening and diagnosis for chlamydia are relatively simple. Tests include:

A urine test. A sample from the first part of the urine stream is tested in the laboratory with a molecular method (NAAT/PCR). It is the preferred sample for men.

A vaginal or cervical sample. For women, a swab is taken from the vagina or cervix and tested with a molecular method (NAAT/PCR), which is now the test of choice. Older cultures and antigen tests are clearly less sensitive and are no longer used as a first choice. The sample can be taken during a Pap test (Pap smear) at a routine checkup.

For men, as an alternative to urine, a sample can be taken from the urethra with a thin swab. When there has been anal or oral sex, samples are also taken from the rectum or throat.

If you have been treated for an initial chlamydia infection, you should be retested in about three months.

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What is the appropriate treatment for immediate management?

Chlamydia trachomatis infection is treated with antibiotics. According to current guidelines, the first choice is doxycycline twice a day for 7 days. Alternatively, for example during pregnancy, azithromycin is given as a single dose.

Avoid sex for 7 days: until you finish the doxycycline course or for 7 days after the single dose of azithromycin, and in any case until your partner has also been treated. Your sexual partner or partners also need treatment even if they have no signs or symptoms. Otherwise, the infection can be passed back and forth between sexual partners.

Having chlamydia or having been treated for it in the past does not prevent you from becoming infected again.

What are the main causes?

In men, chlamydia usually does not present noticeable symptoms. In contrast, women may experience various discharges, discomfort, burning during urination, and vaginal pain. For this reason — and because symptoms tend to appear more clearly — women often realize something is wrong more quickly, making diagnosis relatively prompt.

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Which tests are needed for diagnosis? Can it be detected through a Pap test?

Yes, chlamydia can be detected through a Pap test; however, a Pap smear is typically performed for broader cervical screening purposes. To learn more about the diagnosis and treatment of chlamydia, contact Dr. Polyzos today.

Which chlamydia test is the most reliable

Chlamydia testing has changed in recent years. Older cultures and antigen tests have largely been replaced by molecular methods.

  • Molecular test (PCR or NAAT): it detects the genetic material of the bacterium. It is the most sensitive and specific method and the test of choice according to international guidelines.
  • Vaginal sample: the best sample for women. It can be taken by the doctor or by the woman herself with a swab, with equally reliable results.
  • Urine sample: suitable mainly for men. The first part of the urine stream is collected, at least one hour after last urinating.
  • Throat or rectal sample: when there has been oral or anal sex, because infection at these sites does not show up in the vaginal sample.

Gonorrhea, trichomonas and Mycoplasma genitalium are often tested together in the same sample. Testing can also be done from the liquid-based cytology vial, at the same time as cervical screening.

Chlamydia treatment today

Current guidelines prefer doxycycline for seven days as the first choice, because it is more effective than a single dose of azithromycin, especially when there is a rectal infection. Azithromycin remains an alternative, for example during pregnancy. Your doctor will choose the regimen.

Practical instructions

  • Finish the whole course of treatment, even if you have no symptoms.
  • Take doxycycline with a large glass of water, sitting or standing upright, not right before bed, and protect yourself from the sun.
  • Avoid all sexual contact until both you and your partner have completed treatment.
  • A test of cure is usually not needed, except during pregnancy or when symptoms persist.
  • A new test about three months after treatment is recommended for everyone, because reinfection is common.

Chlamydia in pregnancy

Infection during pregnancy has been linked to premature rupture of the membranes and preterm birth, and it can be passed to the newborn during delivery and cause conjunctivitis or pneumonia.

  • Testing is done early in pregnancy, especially in women under 25 or with risk factors, and is repeated in the third trimester if the risk remains.
  • Treatment uses antibiotics that are safe in pregnancy. Doxycycline is not given.
  • A test of cure is done about four weeks after treatment.

Chlamydia testing is part of prenatal care, so ask your doctor whether it has been done.

How to tell your partner

Telling your partners may be the hardest part, but it is also the most important. Without it, reinfection is almost certain.

  • Who needs to know: all sexual partners from roughly the last 60 days, or your most recent partner if your last sexual contact was earlier.
  • What your partner needs: testing and treatment, even if they have no symptoms or their own test comes back negative.
  • How to say it: simply and without guilt. Chlamydia is very common, often causes no symptoms and can be present for months. A positive test does not show when or from whom the infection was caught.

If you find it difficult, ask your doctor for a written note for your partner with the diagnosis and the treatment needed.

Chlamydia and fertility: what a past infection means

Many women only find out about a past chlamydia infection when they have trouble getting pregnant. A silent infection may have caused pelvic inflammatory disease and damage to the fallopian tubes without any symptoms.

  • During a fertility workup, your doctor may order a blood test for chlamydia antibodies. A positive result indicates past exposure and increases the likelihood of tubal damage.
  • Whether the fallopian tubes are open is checked with hysterosalpingography (HSG) or an equivalent ultrasound test.
  • If the tubes are blocked, options include laparoscopic repair or IVF, depending on the extent of the damage.

The best way to protect your fertility is to get tested with every change of partner and to be treated early.

Frequently Asked Questions

Can I have chlamydia without symptoms?

Yes. About seven in ten women and half of men have no symptoms at all.

The test is reliable about one to two weeks after exposure.

Yes, with antibiotics. It does not leave immunity, so you can be infected again.

Seven days after finishing treatment, and only once your partner has also been treated.

If left untreated, it can travel up to the fallopian tubes and leave damage. Early treatment prevents this complication.

Yes, transmission to the throat is possible, although less common. Throat infection usually causes no symptoms and is tested with a separate throat swab.

Yes. Guidelines recommend treating partners regardless of their test result, because a negative test does not rule out a recent infection.

No. The bacterium does not survive outside the body and is spread only through sexual contact and from mother to newborn during delivery.

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