Institute of Life IASO: IVF Unit in Athens

Dr. Panagiotis Polyzos, obstetrician gynecologist in Athens
Dr. Panagiotis Polyzos MD PhD MSc

Obstetrician-Gynecologist
PhD, University of Athens Medical School

Obstetrician-gynecologist Panagiotis Polyzos practices at the Institute of Life, the IVF Unit of IASO Maternity Hospital.

Contents

Institute of Life assisted reproduction unit

The assisted reproduction unit of IASO hospital

Panagiotis Polyzos is a founding member of the Institute of Life IASO.

The Institute of Life IASO, one of the largest and most advanced Assisted Reproduction Centers in Europe, was established within “IASO”, the leading Maternity and Gynecology Clinic in Greece. It was founded to fulfill our most important mission: to welcome infertile couples and offer them the joy of becoming parents, while ensuring the highest safety standards.

From the moment you visit the Institute of Life IASO, you will notice that our certified, pioneering facility is designed to provide exceptional patient care. With state-of-the-art technology, modern facilities, comfortable spaces, and an innovative air quality monitoring system, we ensure optimal laboratory conditions.

The RI Witness management system, which monitors and records patient samples at every stage of the assisted reproduction process, acts as a safety safeguard, giving our patients peace of mind.

Our scientific team, consisting of leading specialists and co-founders of the center (Panagiotis Psathas, Ioannis Vasilopoulos, Panagiotis Polyzos, Ioannis Zervomanolakis, Konstantinos Kostaras, Stefanos Chandakas, Stylianos Grigorakis, George Kontopoulos, Thomas Prokopakis, Konstantinos Dimitropoulos, Evangelos Dedoulis) as well as the embryology team led by Erotas Nikitos, and including Vania Kallergi, Kristi Agapitou, and Dora Botzaki, is fully dedicated to the needs of each couple, carefully selecting the most suitable treatment plan.

Under the supervision of Dr. Gloria Calderon, the renowned embryologist of the world’s largest IVF center “IVI”, we are confident that we are ready to make our vision a reality: to be a Reproductive Center that serves as a point of reference for couples across Europe.

Services

Every case is unique. Our comprehensive treatments are meticulously tailored to each individual’s needs and aim to achieve the best possible outcomes. Our goal is not to perform miracles — it is to help nature follow its path when it cannot do so on its own.

  • In Vitro Fertilization (IVF)
  • Intrauterine Insemination (IUI)
  • Egg Donation
  • Sperm Donation
  • Surrogacy
  • Fertility Preservation

A couple's journey through an IVF unit, step by step

Every treatment is tailored to the couple, but the basic path in an assisted reproduction unit follows set stages. When you know them in advance, anxiety drops and decisions are made more calmly.

  • First meeting: medical history from both partners, review of previous tests and treatments, transvaginal ultrasound.
  • Investigation: hormone tests, ovarian reserve testing, semen analysis and, where needed, assessment of the uterine cavity and fallopian tubes.
  • Treatment plan: choice of method, from simple ovulation monitoring to IVF, and of the medication protocol.
  • Ovarian stimulation: daily subcutaneous injections for about 8 to 12 days, with ultrasounds and blood tests every few days.
  • Egg retrieval: a short procedure under light sedation, about 36 hours after the trigger injection. See the details of what is involved in egg retrieval.
  • Laboratory stage: fertilization, culture of the embryos and their assessment for 3 to 6 days.
  • Embryo transfer: a painless procedure lasting a few minutes, in a fresh cycle or in a later cycle with a frozen embryo.
  • Pregnancy test: measurement of beta-hCG in the blood about 9 to 12 days after the transfer.

The fertility testing that comes before treatment

The right treatment starts with the right diagnosis. Testing always involves both partners, because in a large share of couples female and male factors coexist.

For the woman

  • Hormones at the start of the cycle (FSH, LH, estradiol), prolactin and thyroid.
  • Anti-Müllerian hormone and an ultrasound antral follicle count, to assess ovarian reserve. More on anti-Müllerian hormone (AMH).
  • Tubal patency testing, when intrauterine insemination (IUI) is planned or when a blockage is suspected.
  • Hysteroscopy, when the ultrasound shows a polyp, septum or adhesions.

For the man

  • Semen analysis after 2 to 5 days of abstinence, according to World Health Organization criteria.
  • Hormonal and genetic testing, when the semen analysis is severely abnormal.
  • Assessment by a urologist-andrologist, where needed.

For the couple

  • Testing for HIV, hepatitis B and C and syphilis, required before any handling of gametes in the laboratory.
  • Blood type, rubella immunity testing and, depending on ancestry, thalassemia carrier testing.

What happens inside the embryology laboratory

The laboratory is the heart of every IVF unit. It is where eggs meet sperm, embryos develop and the decision is made about which one will be transferred. The quality of its work depends on people, protocols and stable conditions.

  • Stable environment: temperature, humidity, gas concentration and air purity are monitored continuously, because embryos are sensitive to small fluctuations.
  • Fertilization: conventional IVF or ICSI, depending on sperm quality and history.
  • Culture to the blastocyst stage: many units culture embryos up to day 5 or 6, so the one with the greatest developmental potential can be selected.
  • Vitrification: rapid freezing that allows embryos and eggs to be preserved for future use with high survival rates.
  • Identification systems: electronic tracking of every sample at every step, to rule out human error.
  • Continuous monitoring of development: incubators with a camera (time-lapse) allow embryos to be monitored without leaving their stable environment.

Fertility preservation: who it is for

A modern reproduction unit does not only help those trying to have a child now. It also helps those who want to keep that option open for the future.

  • Women and men before cancer treatment: chemotherapy and radiation therapy can damage the ovaries and testicles. Freezing eggs, embryos or sperm must be arranged quickly, before cancer treatment begins, in close collaboration with the oncologist.
  • Women who postpone motherhood: the egg freezing option, ideally used at a younger age and before 35, offers better chances later. However, it is not a guarantee of pregnancy.
  • Women with endometriosis or cysts who need ovarian surgery: surgery can reduce ovarian reserve, so the discussion about fertility preservation takes place before the operation.
  • Men with low or declining sperm counts: freezing a sample avoids the need for surgical sperm retrieval in the future.

How to prepare for your first fertility appointment

The first meeting is more productive when you come organized. You do not need to have done tests beforehand, but whatever you have helps avoid losing time.

  • Bring all previous tests for both of you, even old ones: hormones, semen analyses, ultrasounds, pathology reports.
  • Write down the medications and supplements you take, along with the doses.
  • Note the length of your cycles over the last few months and any pain or irregularities.
  • If you have had treatments in the past, keep the protocols, the number of eggs and embryos and the outcome of each attempt.
  • Write your questions down on paper. They are easily forgotten during the conversation.

It is best to come together with your partner. Infertility concerns the couple, and decisions are better made when you both hear the same information.

Questions worth asking at an assisted reproduction unit

Choosing a unit is an important decision. Do not hesitate to ask clearly. A serious team answers without evasion.

  • What is the treatment plan for our case and why is it chosen?
  • Which doctor will follow us at each stage, and who will perform the egg retrieval and the transfer?
  • How many embryos are recommended for transfer, and what are the risks of a multiple pregnancy?
  • What happens to the embryos that are not transferred? How, and for how long, are they preserved?
  • Which tests or add-on techniques are truly necessary for us, and which are optional?
  • How do we contact the team outside office hours if a symptom appears?

A word of caution: the success rates that circulate are often not comparable with one another, because they depend on the women's ages, how they are measured and the type of cases. Ask for an estimate for your own age and diagnosis.

Psychological support, information and the legal framework

Fertility treatment is not just a medical procedure. The waiting, the injections and the uncertainty are tiring, and many couples benefit from talking with a psychologist who knows the field.

In Greece, medically assisted reproduction units operate under license and are supervised by the National Authority for Medically Assisted Reproduction. Before every treatment, a written consent is signed that records the method, what will happen to embryos that are not used and your choices in case of separation or loss of a partner. Read it carefully and ask for clarification on any point that is not clear.

Special cases, such as gamete donation or surrogacy, have additional legal requirements and need a separate discussion.

How the right treatment for each couple is decided

Not everyone starts with IVF. The choice rests on a few but decisive factors:

  • The woman's age: after 35, and even more so after 38, time matters and a more direct approach is often preferred.
  • Condition of the fallopian tubes: if they are blocked, fertilization must take place in the laboratory.
  • Sperm quality: a mild abnormality can be treated with intrauterine insemination (IUI), while a severe one requires ICSI.
  • Ovarian reserve: determines the protocol and the medication doses.
  • Duration of infertility and previous attempts: after several unsuccessful cycles with simpler methods, stepping up treatment makes sense.

The right plan is not the most “advanced” one, but the one that offers realistic chances with the least possible burden.

After the embryo transfer: the days of waiting

The days between the transfer and the pregnancy test are often the hardest emotionally. A few practical points:

  • Continue progesterone support exactly as prescribed. Do not stop it without instructions.
  • Bed rest is not needed. Daily activities and gentle walking are allowed.
  • Avoid home urine tests too early, because they may give a false positive or false negative result.
  • Symptoms such as mild cramps or breast tenderness do not predict the outcome. They are often due to progesterone.
  • Contact us right away if you develop severe pain, bloating, shortness of breath or fever.

What comes after the pregnancy test result

If the test is positive, the beta-hCG measurement is usually repeated a few days later, to see whether it is rising properly. About two weeks later, the first ultrasound is done, which confirms that the pregnancy is inside the uterus and records the number of sacs and, a little later, the heartbeat. From then on, care gradually passes to your obstetrician.

If the test is negative, a review meeting follows. It looks at the ovarian response, the quality of the embryos and the preparation of the uterus, to decide whether to do a frozen embryo transfer, change the protocol or carry out further testing. Give yourself time. Disappointment is normal, and you do not need to decide on the next step the same week.

Treatments

  • Intracytoplasmic Sperm Injection (ICSI)
  • Oocyte Cryopreservation
  • Magnetic Sperm Separation (MACS)
  • Time-lapse
  • Preimplantation Genetic Diagnosis (PGD)
  • Preimplantation Genetic Screening (PGS)
  • Advanced Genetic Testing

 

See more information at www.iolife.eu

Frequently asked questions about the Institute of Life IASO

What is the Institute of Life IASO?

It is an assisted reproduction unit operating within IASO maternity hospital in Athens, with a modern embryology laboratory and a team of specialized gynecologists and embryologists.

Dr. Panagiotis Polyzos is a founding member of the scientific team of the Institute of Life IASO. See his CV.

It is an electronic identification system that tracks and records each couple's samples at every stage of the process, so that the possibility of a mix-up is ruled out.

With a first appointment at Dr. Polyzos' clinic in Athens or Volos, where your medical history is taken and testing for both partners is planned. Schedule an appointment.

From the start of the injections to the pregnancy test, it usually takes four to five weeks. Ovarian stimulation lasts about 8 to 12 days, egg retrieval takes place about 36 hours after the trigger injection, the transfer 3 to 5 days later and the blood test 9 to 12 days after the transfer. If hormonal preparation comes first or the transfer uses a frozen embryo, the timeline is longer.

It is recommended. Testing involves both of you, and the male factor often contributes to infertility. Being there together helps with taking the history, scheduling the tests and the decisions you will make together.

No. Egg retrieval is done under light sedation and usually takes 15 to 20 minutes. After a short recovery stay, a few hours at most, you go home with someone accompanying you. It is best to rest that day and not drive.

Surplus good-quality embryos can be frozen by vitrification and used in a later transfer. The storage period and your choices about their future are recorded in the written consent you sign before treatment.

The data do not show that stress on its own lowers the chance of pregnancy in an IVF cycle. It does, however, affect quality of life and the couple's ability to keep going, that’s why psychological support is so valuable.

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